Browsing by Author "Castro Castillo, Vicente"
Now showing items 1-12 of 12
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(Elsevier, 2013)Anthraquinone derivatives are well-known antiproliferative compounds, and some are currently used in cancer chemotherapy. Some families of annulated anthraquinone analogs have also been examined for antiproliferative ...
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(Elsevier Ltd, 2019)© 2018 1,4-Naphthoquinone derivatives have been widely documented with regard to their biological properties, and particularly their anticancer activities. In the 9,10-anthraquinone family, aza-annulation involving one of ...
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(American Chemical Society, 2014)Tumor cells principally exhibit increased mitochondrial transmembrane potential (Δψm) and altered metabolic pathways. The therapeutic targeting and delivery of anticancer drugs to the mitochondria might improve treatment ...
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(Frontiers Media S.A., 2019)The entactogen MDMA (3,4-methylenedioxy-methamphetamine, “Ecstasy”) exerts its psychotropic effects acting primarily as a substrate of the serotonin transporter (SERT) to induce a non-exocytotic release of serotonin. ...
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CRYSTAL STRUCTURE OF 5,6,8,12b-TETRAHYDRODIOXOLO[4,5-g]ISOINDOLO[1,2-a]ISOQUINOLIN-8-ONE (C17H13NO3) (Sociedad Chilena de Química, 2009-07-03)The title compound was prepared by cyclization of 2-(3,4-methylenedioxyphenyl)ethyl-3-hydroxyisoindolin-1-one in concentrated hydrochloric acid. The compound crystallizes in the orthorhombic space group Pca21 (No. 29) with ...
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(Universidad de Chile, 2020)La sílice es un material prometedor para el desarrollo de nuevos nanomateriales, cuyo uso puede ser de interés para diversas disciplinas como la medicina y las ciencias farmacéuticas. Los distintos tipos de nanopartículas ...
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(Public Library Science, 2015)Chagas disease is one of the most neglected tropical diseases in the world, affecting nearly 15 million people, primarily in Latin America. Only two drugs are used for the treatment of this disease, nifurtimox and benznidazole. ...
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(Elsevier, 2015)Abundant evidence indicates that iron accumulation, oxidative damage and mitochondrial dysfunction are common features of Huntington's disease, Parkinson's disease, Friedreich's ataxia and a group of disorders known as ...
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(Elsevier, 2013)Some synthetic 1-azabenzanthrones (7H-dibenzo[de,h]quinolin-7-ones) are weakly to moderately cytotoxic, suggesting that they might also show antiparasitic activity. We have now tested a small collection of these compounds ...
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(SOC CHILENA QUIMICA, 2009-07-20)The synthesis of 4,5,8,12b-tetrahydroisoindolo[1,2-a]isoquinolin-8-ones is reviewed The unsubstituted parent compound, a series of fourteen A-ring-substituted derivatives, most of them new, and some of their doubly benzylic, ...
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(AMER CHEMICAL SOC, 2010-10-20)Lakshminine (6-amino-1-aza-5-methoxy-7H-dibenzo[de,h]quinolin-7-one, 1) is a recent addition to the small family of oxoisoaporphine alkaloids and a member of an even smaller set bearing an amino group at C-6. This rare ...
